Original articles


Calderon Larrañaga A, Santoni G, Wang HX, Welmer AK, Rizzuto D, Vetrano DL, Fratiglioni L, Marengoni A. Rapidly developing multimorbidity and disability in older adults: does social background matter? J Intern Med. 2018 Feb 7. doi: 10.1111/joim.12739. [Epub ahead of print]

Calderón-Larrañaga A, Vetrano DL, Ferrucci L, Mercer SW, Marengoni A, Onder G, Eriksdotter M, Fratiglioni L. Multimorbidity and functional impairment: bidirectional interplay, synergistic effects and common pathways. J Intern Med. 2018 Oct 24. doi: 10.1111/joim.12843. [Epub ahead of print].

Calderón-Larrañaga A, Fratiglioni L. Multimorbidity research at the crossroads: developing the scientific evidence for clinical practice and health policy. J Intern Med. 2019 Jan 9. doi: 10.1111/joim.12872. [Epub ahead of print] No abstract available.

Ding M, Fratiglioni L, Johnell K, Santoni G, Fastbom J, Ljungman P, Marengoni A, Qiu C. Atrial fibrillation, antithrombotic treatment, and cognitive aging: A population-based study. Neurology. 2018 Nov 6;91(19):e1732-e1740. doi: 10.1212/WNL.0000000000006456. Epub 2018 Oct 10.

Dintica CS, Rizzuto D, Marseglia A, Kalpouzos G, Welmer AK, Wårdh I, Bäckman L, Xu W. Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study. Neurobiol Aging. 2018 Jul

Dintica CS, Marseglia A, Rizzuto D, Wang R, Seubert J, Arfanakis K, Bennett DA, Xu W. Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain. Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006919. doi: 10.1212/WNL.0000000000006919. [Epub ahead of print]

Ek S, Rizzuto D, Fratiglioni L, Johnell K, Xu W, Welmer AK. Risk Profiles for Injurious Falls in People Over 60: A Population-Based Cohort Study. J Gerontol A Biol Sci Med Sci. 2018 Jul;67:23-30. doi: 10.1016/j.neurobiolaging.2018.03.003. Epub 2018 Mar 9

Ek S, Rizzuto D, Fratiglioni L, Calderón-Larrañaga A, Johnell K, Sjöberg L, Xu W, Welmer AK.Risk Factors for Injurious Falls in Older Adults: The Role of Sex and Length of Follow-Up. J Am Geriatr Soc. 2018 Nov 29. doi: 10.1111/jgs.15657. [Epub ahead of print

Haaksma ML, Calderón-Larrañaga A, Olde Rikkert MGM, Melis RJF, Leoutsakos JS. Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry. 2018 Aug;33(8):1057-1064. doi: 10.1002/gps.4893. Epub 2018 May 15.

Heiland EG, Welmer AK, Wang R, Santoni G, Fratiglioni L, Qiu C. Cardiovascular Risk Factors and the Risk of Disability in Older Adults: Variation by Age and Functional Status. J Am Med Dir Assoc. 2019 Feb;20(2):208-212.e3. doi: 10.1016/j.jamda.2018.05.013. Epub 2018 Jul 10.

Marseglia A, Dahl Aslan AK, Fratiglioni L, Santoni G, Pedersen NL, Xu W. Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study. J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):400-406. doi: 10.1093/gerona/glx112.

Marseglia A, Fratiglioni L, Kalpouzos G, Wang R, Bäckman L, Xu W. Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study. Alzheimers Dement. 2019 Jan;15(1):25-33. doi: 10.1016/j.jalz.2018.06.3060. Epub 2018 Aug 13.

Marseglia A, Wang HX, Rizzuto D, Fratiglioni L, Xu W.Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults. Diabetes Care. 2019 Feb;42(2):232-239. doi: 10.2337/dc18-1428. Epub 2018 Dec 6.

Pan KY, Xu W, Mangialasche F, Dekhtyar S, Fratiglioni L, Wang HX. Working Life Psychosocial Conditions in Relation to Late-Life Cognitive Decline: A Population-Based Cohort Study. J Alzheimers Dis. 2019;67(1):315-325. doi: 10.3233/JAD-180870.

Payton NM, Kalpouzos G, Rizzuto D, Fratiglioni L, Kivipelto M, Bäckman L, Laukka EJ. Combining Cognitive, Genetic, and Structural Neuroimaging Markers to Identify Individuals with Increased Dementia Risk. J Alzheimers Dis. 2018

Prinelli F, Fratiglioni L, Musicco M, Johansson I, Adorni F, Shakersain B, Rizzuto D, Xu W. The impact of nutrient-based dietary patterns on cognitive decline in older adults. Clin Nutr. 2018 Dec 14. pii: S0261-5614(18)32580-9. doi: 10.1016/j.clnu.2018.12.012. [Epub ahead of print]

Qiu C, Fratiglioni L. Aging without Dementia is Achievable: Current Evidence from Epidemiological Research. J Alzheimers Dis. 2018;64(2):533-542. doi: 10.3233/JAD-180199.

Rennemark M, Jogréus C, Elmståhl S, Welmer AK, Wimo A, Sanmartin-Berglund J. Relationships Between Frequency of Moderate Physical Activity and Longevity: An 11-Year Follow-up Study. Gerontol Geriatr Med. 2018 Jul 20;4:2333721418786565. doi: 10.1177/2333721418786565. eCollection 2018 Jan-Dec.

Santoni G, Angleman SB, Ek S, Heiland EG, Lagergren M, Fratiglioni L, Welmer AK. Temporal trends in impairments of physical function among older adults during 2001-16 in Sweden: towards a healthier ageing. Age Ageing. 2018 Sep 1;47(5):698-704. doi: 10.1093/ageing/afy085.

Santoni G, Calderón-Larañaga A, Vetrano DL, Welmer AK, Orsini N, Fratiglioni L.Geriatric health charts for individual assessment and prediction of care needs: a population-based prospective study. J Gerontol A Biol Sci Med Sci. 2018 Dec 4. doi: 10.1093/gerona/gly272. [Epub ahead of print]

Santoni G, Meinow B, Wimo A, Marengoni A, Fratiglioni L, Calderón-Larrañaga A. Using an Integrated Clinical and Functional Assessment Tool to Describe the Use of Social and Medical Care in an Urban Community-Dwelling Swedish Older Population. J Am Med Dir Assoc. 2019 Jan 17. pii: S1525-8610(18)30666-2. doi: 10.1016/j.jamda.2018.11.017. [Epub ahead of print]

Shakersain B, Rizzuto D, Larsson SC, Faxén-Irving G, Fratiglioni L, Xu WL. The Nordic Prudent Diet Reduces Risk of Cognitive Decline in the Swedish Older Adults: A Population-Based Cohort Study. Nutrients. 2018 Feb 17;10(2). pii: E229. doi: 10.3390/nu10020229.

Shakersain B, Rizzuto D, Wang HX, Faxén-Irving G, Prinelli F, Fratiglioni L, Xu W. An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study. Nutrients. 2018 Sep 13;10(9). pii: E1297. doi: 10.3390/nu10091297.

Sindi S, Johansson L, Skoog J, Mattsson AD, Sjöberg L, Wang HX, Fratiglioni L, Kulmala J, Soininen H, Solomon A, Johansson B, Skoog I, Kivipelto M, Kåreholt I. Sleep disturbances and later cognitive status: a multi-centre study. Sleep Med. 2018 Dec;52:26-33. doi: 10.1016/j.sleep.2017.11.1149. Epub 2018 Jan 3.

Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang HX, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M. Sleep disturbances and dementia risk: A multicenter study. Alzheimers Dement. 2018 Oct;14(10):1235-1242. doi: 10.1016/j.jalz.2018.05.012. Epub 2018 Jul 17.

Tan ECK, Qiu C, Liang Y, Wang R, Bell JS, Fastbom J, Fratiglioni L, Johnell K. Antihypertensive Medication Regimen Intensity and Incident Dementia in an Older Population. J Am Med Dir Assoc. 2018 Jul;19(7):577-583. doi: 10.1016/j.jamda.2017.11.017. Epub 2018 Jan 3

Trevisan C, Crippa A, Ek S, Welmer AK, Sergi G, Maggi S, Manzato E, Bea JW, Cauley JA, Decullier E, Hirani V, LaMonte MJ, Lewis CE, Schott AM, Orsini N, Rizzuto D. Nutritional Status, Body Mass Index, and the Risk of Falls in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2018 Dec 13. pii: S1525-8610(18)30607-8. doi: 10.1016/j.jamda.2018.10.027. [Epub ahead of print] Review.

Wang R, Laveskog A, Laukka EJ, Kalpouzos G, Bäckman L, Fratiglioni L, Qiu C. MRI load of cerebral microvascular lesions and neurodegeneration, cognitive decline, and dementia. Neurology. 2018 Oct 16;91(16):e1487-e1497. doi: 10.1212/WNL.0000000000006355. Epub 2018 Sep 19.

Vetrano DL, Calderón-Larrañaga A, Marengoni A, Onder G, Bauer JM, Cesari M, Ferrucci L, Fratiglioni L. An International Perspective on Chronic Multimorbidity: Approaching the Elephant in the Room. J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1350-1356. doi: 10.1093/gerona/glx178

Vetrano DL, Rizzuto D, Calderón-Larrañaga A, Onder G, Welmer AK, Bernabei R, Marengoni A, Fratiglioni L. Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: A Swedish cohort study. PLoS Med. 2018 Mar 6;15(3):e1002503. doi: 10.1371/journal.pmed.1002503. eCollection 2018 Mar

Zuidersma M, Sjöberg L, Pantzar A, Fratiglioni L, Wang HX. A bi-factor model of the Montgomery Åsberg depression rating scale and future cognitive impairments in older adults: A 6-year follow-up study. J Psychiatr Res. 2019 Feb;109:1-9. doi: 10.1016/j.jpsychires.2018.11.010. Epub 2018 Nov 10

Zucchelli A, Vetrano DL, Marengoni A, Grande G, Romanelli G, Calderón-Larrañaga A, Fratiglioni L, Rizzuto D. Frailty predicts short-term survival even in older adults without multimorbidity. Eur J Intern Med. 2018 Oct;56:53-56. doi: 10.1016/j.ejim.2018.06.012. Epub 2018 Jun 24.


Calderón-Larrañaga A, Vetrano DL, Onder G, Gimeno-Feliu LA, Coscollar-Santaliestra C, Carfí, Pisciotta M, Angleman S, Melis RJF, Santoni G, Mangialasche F, Rizzuto D, Welmer AK, Bernabei R, Prados-Torres A, Marengoni A, Fratiglioni L. Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization. J Gerontol A Biol Sci Med Sci. 2017;72(10):1417-1423.

Ding M, Fratiglioni L, Johnell K, Fastbom J, Ljungdahl M, Qiu C. Atrial fibrillation and use of antithrombotic medications in older people: A population-based study. Int J Cardiol. 2017.

Ferreira D, Hansson O, Barroso J, Molina Y, Machado A, Hernandez-Cabrera JA, et al. The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals. Hippocampus. 2017;27(6):653-667.

Gerritsen L, Wang HX, Reynolds CA, Fratiglioni L, Gatz M, Pedersen N. Influence of negative life events and widowhood on risk for dementia. Am J Geriatr Psychiatry. 2017;25(7):766-778.

Heiland EG, Qiu C, Wang R, Santoni G, Liang Y, Fratiglioni L, et al. Cardiovascular risk burden and future risk of walking speed limitation in older adults. Journal of the American Geriatrics Society. 2017;65(11):2418-24.

Laveskog A, Wang R, Bronge L, Wahlund LO, Qiu C. Perivascular spaces in old age: assessment, distribution, and correlation with white matter hyperintensities. Am J Neuroradiol. 2017.

Liang Y, Vetrano DL, Qiu C. Serum total cholesterol and risk of cardiovascular and non-cardiovascular mortality in old age: a population-based study. BMC Geriatrics 2017;17:294.

Pan KY, Xu W, Mangialasche F, Fratiglioni L, Wang HX. Work-related psychosocial stress and the risk of type 2 diabetes in later life. Journal of internal medicine. 2017;[Epub ahead of print].

Pantzar A, Atti AR, Fratiglioni L, Fastbom J, Bäckman L, Laukka EJ. Cognitive performance in unipolar old-age depression: A longitudinal study. International Journal of Geriatric Psychiatry. 2017;32(6):675-684

Papenberg G, Becker N, Ferencz B, Naveh-Benjamin M, Laukka EJ, Bäckman L, et al. Dopamine receptor genes modulate associative memory in old age. J Cogn Neurosci. 2017;29(2):245-53.

Papenberg G, Bäckman L, Fratiglioni L, Laukka EJ, Fastbom J, Johnell K. Anticholinergic drug use is associated with episodic memory decline in older adults without dementia. Neurobiology of aging. 2017;55:27-32.

Rizzuto D, Feldman AL, Karlsson IK, Dahl Aslan AK, Gatz M, Pedersen NL. Detection of Dementia Cases in Two Swedish Health Registers: A Validation Study J Alzheimers Dis. 2018;61(4):1301-1310

Rizzuto D, Melis RJ, Angleman S, Qiu C, Marengoni A. Effect of chronic diseases and multimorbidity on survival and functioning in elderly adults. Journal of the American Geriatrics Society. 2017;65(5):1056-60.

Rizzuto D, Mossello E, Fratiglioni L, Santoni G, Wang HX. Personality and survival in older age: the role of lifestyle behaviors and health status. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2017.

Santoni G, Marengoni A, Calderón-Larrañaga A, Angleman S, Rizzuto D, Welmer AK, Mangialasche F, Orsini N, Fratiglioni L. Defining Health Trajectories in Older Adults With Five Clinical Indicators. J Gerontol A Biol Sci Med Sci. 2017;72(8):1123-1129

Seubert J, Laukka EJ, Rizzuto D, Hummel T, Fratiglioni L, Bäckman L, et al. Prevalence and correlates of olfactory dysfunction in old age: a population-based study. The journals of gerontology Series A, Biological sciences and medical sciences. 2017;[Epub ahead of print].

Sjöberg L, Karlsson B, Atti AR, Skoog I, Fratiglioni L, Wang HX. Prevalence of depression: Comparisons of different depression definitions in population-based samples of older adults. J Affect Disord. 2017;221:123-31.

Sjölund S, Larsson M, Olofsson JK, Seubert J, Laukka EJ. Phantom smells: prevalence and correlates in a population-based sample of older adults. Chem Senses. 2017;42(4):309-18.

Tuvesson H, Hellström A, Sjöberg L, Sjölund BM, Nordell E, Fagerström C. Life weariness and suicidal thoughts in late life: a national study in Sweden. Aging Ment Health. 2017:1-7.

Wang H, MacDonald S, Dekhtyar S, Fratiglioni L. Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study. PLoS Med. 2017;14(3):e1002251

Wang R, Fratiglioni L, Kalpouzos G, Lövdén M, Laukka EJ, Bronge L, et al. Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2017;13(3):247-56.

Welmer AK, Rizzuto D, Calderón-Larrañaga A, Johnell K. Sex differences in the association between pain and injurious falls in older adults: a population-based longitudinal study. American journal of epidemiology. 2017.

Welmer AK, Rizzuto D, Laukka EJ, Johnell K, Fratiglioni L. Cognitive and physical function in relation to the risk of injurious falls in older adults: a population-based study. The journals of gerontology Series A, Biological sciences and medical sciences. 2017;72(5):669-75.


Becker N, Kalpouzos G, Persson J, Laukka EJ, Brehmer Y. Differential effects of encoding instructions on brain activity patterns of item and associative memory. J Cognitive Neurosci. 2017;29(3):545-559.

Craftman AG, Johnell K, Fastbom J, Westerbotn M, von Strauss E. Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden. Arch Gerontol Geriatr. 2016;63:28-35.

Gnjidic D, Fastbom J, Fratiglioni L, Rizzuto D, Angleman S, Johnell K. Statin therapy and dementia in older people: role of disease severity and multimorbidity. Journal of the American Geriatrics Society. 2016;64(1):223-4.

Heiland E, Welmer AK, Wang R, Santoni G, Angleman S, Fratiglioni L, et al. Association of mobility limitations with incident disability among older adults: a population-based study. Age Ageing. 2016;45(6):812-819.

Hooshmand B, Mangialasche F, Kalpouzos G, Solomon A, Kåreholt I, Smith AD, et al. Association of vitamin B12, folate, and sulfur amino acids with brain magnetic resonance imaging measures in older adults: a longitudinal population-based study. JAMA Psychiatry. 2016;73(6):606-13.

Karlsson B, Johnell K, Sigstrom R, Sjöberg L, Fratiglioni L. Depression and depression treatment in a population-based study of individuals over 60 years old without dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2016;24(8):615-23.

Khan W, …, Bäckman L, Fratiglioni L, Kalpouzos G, et al, Alzheimer–s Disease Neuroimaging Initiative; AddNeuroMed Consortium, Australian, Imaging, Biomarkers, and Lifestyle Study Research Group; IMAGEN consortium. A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer’s Disease. J Alzheimers Dis. 2017;56(3):1159-1174.

Köhncke Y, Laukka EJ, Brehmer Y, Kalpouzos G, Li TQ, Fratiglioni L, et al. Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older. Neurobiology of aging. 2016;41:173-86.

Larsson M, Hedner M, Papenberg G, Seubert J, Backman L, Laukka EJ. Olfactory memory in the old and very old: relations to episodic and semantic memory and APOE genotype. Neurobiology of aging. 2016;38:118-26.

Liang Y, Fratiglioni L, Wang R, Santoni G, Welmer AK, Qiu C. Effects of biological age on the associations of blood pressure with cardiovascular and non-cardiovascular mortality in old age: A population-based study. Int J Cardiol. 2016;220:508-13.

Liang Y, Vetrano DL, Qiu C. The role of biological age in the management of hypertension in old age: Does SPRINT tell the whole story? Int J Cardiol. 2016;222:699-700.

Marengoni A, Angleman S, Meinow B, Santoni G, Mangialasche F, Rizzuto D, et al. Coexisting chronic conditions in the older population: variation by health indicators. Eur J Intern Med. 2016;31:29-34.

Marseglia A, Fratiglioni L, Laukka EJ, Santoni G, Pedersen NL, Bäckman L, et al. Early cognitive deficits in type 2 diabetes: a population-based study. Journal of Alzheimer’s disease : JAD. 2016;53(3):1069-78.

Papenberg G, Ferencz B, Mangialasche F, Mecocci P, Cecchetti R, Kalpouzos G, Fratiglioni L, Bäckman L. Physical activity and inflammation: Effects on gray-matter volume and cognitive decline in aging. Human Brain Mapping. 2016;37, 3462-3473.

Pimouguet C, Rizzuto D, Schön P, Shakersain B, Angleman S, Lagergren M, et al. Impact of living alone on institutionalization and mortality: a population-based longitudinal study. European journal of public health. 2016;26(1):182-7.

Pimouguet C, Rizzuto D, Fastbom J, Lagergren M, Fratiglioni L, Xu W. Influence of Incipient Dementia on Hospitalization for Primary Care Sensitive Conditions: A Population-Based Cohort Study. J Alzheimers Dis. 2016 Mar 8;52(1):213-22.

Rizzuto D, Keller L, Orsini N, Graff C, Backman L, Bellocco R, et al. Effect of the interplay between genetic and behavioral risks on survival after age 75. Journal of the American Geriatrics Society. 2016;64(12):2440-2447.

Schön P, Lagergren M, Kåreholt I. Rapid decrease in length of stay in institutional care for older people in Sweden between 2006 and 2012: results from a population-based study. Health Soc Care Community. 2016;24(5):631-8.

Sköldunger A, Fastbom J, Wimo A, Fratiglioni L, Johnell K. The impact of dementia on drug costs in older people: results from the SNAC study. BMC Neurol. 2016;16:28.

Dekhtyar S, Wang HX, Fratiglioni L, Herlitz A. Childhood school performance, education and occupational complexity: a life-course study of dementia in the Kungsholmen Project. International journal of epidemiology. 2016;45(4):1207-15.

Welmer AK, Rizzuto D, Parker MG, Xu W. Impact of tooth loss on walking speed decline over time in older adults: a population-based cohort study. Aging Clin Exp Res. 2017;29(4):793-800

Wimmer BC, Bell JS, Fastbom J, Wiese MD, Johnell K. Medication regimen complexity and polypharmacy as factors associated with all-cause mortality in older people: a population-based cohort study. Ann Pharmacother. 2016;50(2):89-95.

Wimmer BC, Bell JS, Fastbom J, Wiese MD, Johnell K. Medication regimen complexity and number of medications as factors associated with unplanned hospitalizations in older people: a population-based cohort study. The journals of gerontology Series A, Biological sciences and medical sciences. 2016;71(6):831-7.


Angleman SB, Santoni G, Pilotto A, Fratiglioni L, Welmer AK, Investigators MAP. Multidimensional prognostic index in association with future mortality and number of hospital days in a population-based sample of older adults: results of the EU funded MPI_AGE project. PloS one. 2015;10(7):e0133789.

Becker N, Laukka EJ, Kalpouzos G, Naveh-Benjamin M, Backman L, Brehmer Y. Structural brain correlates of associative memory in older adults. NeuroImage. 2015;118:146-53.

Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, et al. Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the multi-center ESCAPE project. Environ Health Perspect. 2015;123(6):525-33.

Dekhtyar S, Wang HX, Scott K, Goodman A, Koupil I, Herlitz A. A life-course study of cognitive reserve in dementia: from childhood to old age. Am J Geriatr Psychiatry. 2015;23(9):885-96.

Fastbom J, Johnell K. National indicators for quality of drug therapy in older persons: the Swedish experience from the first 10 years. Drugs Aging. 2015;32(3):189-99.

Gerritsen L, Kalpouzos G, Westman E, Simmons A, Wahlund LO, Bäckman L, et al. The influence of negative life events on hippocampal and amygdala volumes in old age: a life-course perspective. Psychol Med. 2015;45(6):1219-28.

Gransjön Craftman Å, Westerbotn M, von Strauss E, Hillerås P, Marmstal Hammar L. Older people’s experience of utilisation and administration of medicines in a health- and social care context. Scand J Caring Sci. 2015.

Gransjön Craftman Å, Johnell K, Fastbom J, Westerbotn M, von Strauss E. Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden. Arch Gerontol Geriatr. 2016;63:28-35.

Kalpouzos G, Rizzuto D, Keller L, Fastbom J, Santoni G, Angleman S, Graff C, Bäckman L, Fratiglioni L. Telomerase Gene (hTERT) and Survival: Results From Two Swedish Cohorts of Older Adults. J Gerontol A Biol Sci Med Sci. 2016;71(2):188-95.

Korek MJ, Bellander TD, Lind T, Bottai M, Eneroth KM, Caracciolo B, et al. Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm. J Expo Sci Environ Epidemiol. 2015; 25(5):517-23

Lagergren M, Fagerström C, Sjölund BM, Berglund J, Fratiglioni L, Nordell E, von Strauss E, Wimo A, Elmståhl S. Horizontal and vertical targeting: a population-based comparison of public eldercare services in urban and rural areas of Sweden. Aging Clin Exp Res. 2016;28(1):147-58.

Laukka EJ, Lovden M, Kalpouzos G, Papenberg G, Keller L, Graff C, et al. Microstructural white matter properties mediate the association between APOE and perceptual speed in very old persons without dementia. PloS one. 2015;10(8):e0134766.

Mangialasche F, Baglioni M, Cecchetti R, Kivipelto M, Ruggiero C, Piobbico D, et al. Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer’s disease and mild cognitive impairment. J Alzheimers Dis. 2015;44(2):649-60.

Osmanovic-Thunstrom A, Mossello E, Åkerstedt T, Fratiglioni L, Wang HX. Do levels of perceived stress increase with increasing age after age 65? A population-based study. Age Ageing. 2015;44(5):828-34.

Pantzar A, Atti AR, Backman L, Laukka EJ. Effects of psychiatric history on cognitive performance in old-age depression. Front Psychol. 2015;6:865.

Papenberg G, Lovden M, Laukka EJ, Kalpouzos G, Keller L, Graff C, et al. Magnified effects of the COMT gene on white-matter microstructure in very old age. Brain Struct Funct. 2015;220(5):2927-38.

Pimouguet C, Le-Goff M, Rizzuto D, Berr C, Leffondre K, Peres K, et al. Effect of early referral to specialist in dementia on institutionalization and functional decline: findings from a population-based study. J Alzheimers Dis. 2015;49(3):819-28

Santoni G, Angleman S, Welmer AK, Mangialasche F, Marengoni A, Fratiglioni L. Age-related variation in health status after age 60. PloS one. 2015;10(3):e0120077.

Shakersain B, Santoni G, Faxen-Irving G, Rizzuto D, Fratiglioni L, Xu W. Nutritional status and survival among old adults: an 11-year population-based longitudinal study. Eur J Clin Nutr. 2015; Jul 8. doi: 10.1038/ejcn.2015.109. [Epub ahead of print]

Shakersain B, Santoni G, Larsson SC, Faxen-Irving G, Fastbom J, Fratiglioni L, et al. Prudent diet may attenuate the adverse effects of Western diet on cognitive decline. Alzheimers Dement. 2016 Feb;12(2):100-9

Sköldunger A, Fastbom J, Wimo A, Fratiglioni L, Johnell K. Impact of inappropriate drug use on hospitalizations, mortality, and costs in older persons and persons with dementia: findings from the SNAC study. Drugs Aging. 2015;32(8):671-8.

Wang R, Fratiglioni L, Laukka EJ, Lövdén M, Kalpouzos G, Keller L, et al. Effects of vascular risk factors and APOE epsilon4 on white matter integrity and cognitive decline. Neurology. 2015;84(11):1128-35.

Wang R, Fratiglioni L, Liang Y, Welmer AK, Xu W, Mangialasche F, et al. Prevalence, pharmacological treatment, and control of cardiometabolic risk factors among older people in central Stockholm: a population-based study. PloS one. 2015;10(3):e0119582.

Wu YT, Fratiglioni L, Matthews FE, Lobo A, Breteler MM, Skoog I, et al. Dementia in western Europe: epidemiological evidence and implications for policy making. Lancet Neurol. 2016;15(1):116-24.

Xu WL, Pedersen NL, Keller L, Kalpouzos G, Wang HX, Graff C, et al. HHEX_23 AA genotype exacerbates effect of diabetes on dementia and Alzheimer disease: a population-based longitudinal study. PLoS Med. 2015;12(7):e1001853.

Åkerborg Ö, Lang A, Wimo A, Sköldunger A, Fratiglioni L, Gaudig M, Rosenlund M. Cost of Dementia and Its Correlation With Dependence. J Aging Health. 2016 Jan 26. pii: 0898264315624899. [Epub ahead of print]


Angleman SB, Santoni G, Von Strauss E, Fratiglioni L. Temporal Trends of Functional Dependence and Survival Among Older Adults From 1991 to 2010 in Sweden: Toward a Healthier Aging. J Gerontol A Biol Sci Med Sci 2014 Nov 13. [Epub ahead of print]

Anstey KJ, Cherbuin N, Herath PM, Qiu C, Kuller LH, Wilson R, Fratiglioni L. A self-report risk index to predict occurrence of dementia in three independent cohorts: The ANU-ADRI. PLoS ONE 2014; 9(1):e86141.

Beelen et al. Effects of long-term exposure to air pollution on natural cause mortality: an analysis of 22 European cohorts within the multi-center ESCAPE project. The Lancet 2014; 383(9919):785-95.

Beelen R, Stafoggia M, Rasschou-Nielsen O, Andersen Z, Xun W, Katsouyanni K, et al., Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts within the ESCAPE project. Epidemiology 2014; 25(3):368-78.

Berner J, Rennemark M, Jogréus C, Anderberg P, Sköldunger A, Wahlberg M, Elmståhl S, Berglund J. Factors influencing Internet usage in older adults (65 years and above) living in rural and urban Sweden. Health Informatics J 2014 Feb 24. [Epub ahead of print]

Cesaroni G, Forastiere F, Stafoggia M, Andersen ZJ, Badaloni C, Beelen R, et al. Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ 2014; 348:f7412.

Dimakopoulou K, Samoli E, Beelen R, Stafoggia M, Andersen ZJ, Hoffmann B, et al. Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project. Am J Respir Crit Care Med 2014; 189(6):684-96.

Ding M, Wang R, Johnell K, Qiu C. Patterns of cardiovascular drug therapy in an elderly Swedish population. Int J Cardiol 2014;177(3):1091-4.

Escott-Price V, Fratiglioni L et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer’s disease. PLoS One 2014; 12;9(6):e94661.

Ferencz B, Laukka EJ, Welmer AK, Kalpouzos K, Angleman S, Keller L, Graff C, Lövdén M, Bäckman L. The benefits of staying active in old age: Physical activity counteracts the negative influence of PICALM, BIN1 and CLU risk alleles on episodic memory functioning. Psychol Aging 2014; 29:440-449

Fuks KB, Caracciolo B, Fratiglioni L et al. Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect 2014; 122(9):896-905.

Gerritsen L, Kalpouzos G, Westman E, Simmons A, Wahlund L O, Bäckman L, Fratiglioni L, Wang HX. The influence of negative life events on hippocampal and amygdala volumes in old age: A life-course perspective. Psychol Med 2014; 2:1-10.

Hahn EA, Wang HX, Andel R, Fratiglioni L. A Change in Sleep Pattern May Predict Alzheimer’s disease. Am J Geriatri Psychiatr 2013 Aug 13. [Epub ahead of print]

Irz X, Fratiglioni L, Kuosmanen N, Mazzocchi M, Modugno L, Nocella G, Shakersain B, Traill B, Xu WL, Zanello G. Socio-demographic determinants of diet quality of the EU elderly: A comparative analysis in four countries. Public Health Nutr 2014; 17(5):1177-89.

Larsson K, Kåreholt I, Thorslund M. Care utilisation in the last years of life in Sweden: The effects of gender and marital status differ by type of care. Eur J Ageing 2014; 11(4):1-11.

Liang Y, Johnell K, Yan Z, Cai C, Jiang H, Welmer AK, Qiu C. Use of medications and functional dependence among Chinese older adults in a rural community: A population-based study. Geriatr Gerontol Int 2015 Jan 17. [Epub ahead of print]

Lövdén, M, Köhncke, Y, Laukka, E J, Kalpouzos, G, Salami, A, Li, T-Q, Fratiglioni, L, Bäckman, L. Changes in perceptual speed and white matter microstructure in the corticospinal tract are associated in very old age. Neuroimage 2014; 102, 520-530.

Marseglia A, Xu W, Rizzuto D, Ferrari C, Whisstock C, Brocco E, Fratiglioni L, Crepaldi G, Maggi S. Cognitive functioning among patients with diabetic foot. J Diabetes Complications 2014; 28(6):863-8.

Melis R, Marengoni A, Angleman S, Fratiglioni L. Incidence and predictors of multimorbidity in the elderly: a population-based longitudinal study. PLoS One 2014; 24;9(7):e103120.

Melis R, Marengoni A, Rizzuto D, Teerenstra S, Kivipelto M, Angleman S, Fratiglioni L. The influence of multimorbidity on clinical progression of dementia in a population-based cohort. PLoS One 2013; 30;8(12):e84014.

Pantzar A, Laukka EJ, Atti AR, Papenberg G, Keller L, Graff C, Fratiglioni L, Bäckman L. Interactive effects of KIBRA and CLSTN2 polymorphisms on episodic memory in old-age unipolar depression. Neuropsychologia 2014; 62:137-142.

Pantzar, A, Laukka, E J, Atti, A R, Fastbom, J, Fratiglioni, L, Bäckman, L. Cognitive deficits in unipolar old-age depression: A population-based study. Psychological Medicine 2014; 44, 937-947.

Wang M, Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen ZJ, Hoffmann B, et al. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ Int 2014; 66:97-106.

Wang R, Fratiglioni L, Laveskog A, Kalpouzos G, Ehrenkrona CH, Zhang Y, Bronge L, Wahlund LO, Bäckman L, Qiu C. Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? A population-based study. Eur J Neurol 2014; 21(8):1076-82.

Welmer AK, Liang Y, Angleman S, Santoni G, Yan Z, Cai C, Qiu C. Vascular risk factor burden, atherosclerosis, and functional dependence in old age: a population-based study. Int J Behav Med 2014; 21:597-604.

Welmer A-K, Rizzuto D, Qiu C X, Caracciolo B, Laukka EJ. Walking speed, processing speed, and dementia: A population-based longitudinal study. J Gerontol A Biol Sci Med Sci [In press:online] 2014.

Xu W, Wang Y, Caracciolo B, Wang H, Santoni G, Fratiglioni L. Enhanced risk of mild cognitive impairment and its progression to dementia among APOE ɛ4 carriers. J Alzheimers Dis 2013; 33(2):507-15.


Ferencz B, Laukka EJ, Lövdén M, Kalpouzos G, Keller L, Graff C, Wahlund LO, Fratiglioni L, Bäckman L. The influence of the APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age. Front Hum Neurosci. Available from: doi: 10.3389/fnhum.2013.00198

Handels RL, Xu W, Rizzuto D, Caracciolo B, Wang R, Winblad B, et al. Natural Progression Model of Cognition and Physical Functioning among People with Mild Cognitive Impairment and Alzheimer’s Disease. J Alzheimers Dis. [In press: online] 2013. Available from: doi 10.3233/JAD-130296.

Laukka EJ, Lövdén M, Herlitz A, Karlsson S, Ferencz B, Pantzar A, Keller L, Graff C, Fratiglioni L,Bäckman L. Genetic effects on old-age cognitive functioning: A population-based study. Psychol Aging. 2013;28(1):262-74.

Laukka EJ, Lövdén M, Kalpouzos G, Li TQ, Jonsson T, Wahlund LO, Fratiglioni L, Bäckman L. Associations between white matter microstructure and cognitive performance in old and very old agePLOS ONE November 2013 Volume 8 Nr 11

Lövdén M, Laukka EJ, Rieckmann A, Kalpouzos G, Li T-Q, Jonsson T, et al. The dimensionality of between-person differences in white matter microstructure in old age. Hum Brain Mapp. 2013;34:1386-1398.

Melis RJF, Marengoni A, Rizzuto D, Teerenstra S, Kivipelto M, Angleman S, Fratiglioni L. Multimorbidity and dementia progression: The influence of multimorbidity on clinical progression of Dementia in a population-based cohort PLOS ONE | www.plosone.org 10 December 2013 | Volume 8 | Issue 12 | e84014

Pantzar A, Laukka EJ, Atti AR, Fastbom J, Fratiglioni L, Bäckman L. Cognitive deficits in unipolar old-age depression: A population-based study. Psychol Med 2013; 10:1-11

Qiu C, von Strauss E, Bäckman L, Winblad B, Fratiglioni L. 20-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology 2013;80:1888-1894.

Raaschou-Nielsen O, Andersen ZJ, Beelen R, Samoli E, Stafoggia M, Weinmayr G, et al. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol 2013; 14(9):813-822.

Rydwik E, Welmer AK, Angleman S, Fratiglioni L, Wang HX. Is Midlife Occupational Physical Activity Related to Disability in Old Age? The SNAC-Kungsholmen Study. PLoS One. 2013; 30;8(7):e70471.

Sjölund B-M, Wimo A, Qiu C, Engström M, von Strauss E. Time trends in prevalence of ADL disability and survival: comparing two populations (aged 78+ years) living in a rural area in Sweden. Arch Gerontol Geriatr 2013 Dec 27. pii: S0167-4943(13)00196-9. doi: 10.1016/j.archger.2013.12.004.

Sköldunger A, Johnell K, Winblad B, Wimo A. Mortality and treatment costs have a great impact on the cost-effectiveness of disease modifying treatment in Alzheimer’s disease–a simulation study. Curr Alzheimer Res 2013;10:207-16

Welmer A-K, Angleman S, Rydwik E, Fratiglioni L, Qiu C. Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study. PLoS ONE 2013; 8(5): e65815.

Welmer AK, Kåreholt I, Rydwik E, Angleman S, Wang HX. Education-related differences in physical performance after age 60: a cross-sectional study assessing variation by age, gender and occupation. BMC Public Health 2013; 13:641.

Lagergren M, Fratiglioni L, Rahm Hallberg I, Berglund J, Elmståhl S, Hagberg B, Holst G, Rennemark M, Sjölund B-M, Thorslund M, Wiberg I, Winblad B, Wimo A. A longitudinal study integrating population, care and social services data. The Swedish National study on Aging and Care (SNAC). Aging Clin Exp Res 2004;16:158-168.